Izanaki & Izanami (the first married couple of Japan)

Izanagi and Izanami descend to Onogoro Island, build the Heavenly Pillar and the Eight-Fathom Palace, and give birth to Hiruko, depicted in a single manga page.

The couple was unable to conceive successfully.

Husband Izanaki and wife Izanami, having descended upon Onogoro Island, built the Heavenly Pillar(Ame no Mihashira) and a great divine hall (Yahiro Dono)
They examined each other’s bodies and decided to join what was lacking with what was in excess, intending to create a land.

Izanagi circled the Heavenly Pillar to the left, while Izanami circled to the right, and it was the wife Izanami who first spoke to her husband.

Hiruko

And the children born were Hiruko and bubbles. Hiruko was a child without arms or legs. He was placed on a reed boat and cast adrift.
Because he had no bones like a leech and was physically impaired, he was regarded as a failure. However, shrines dedicated to Hiruko still exist today, and he later came to be worshiped as a deity of prosperous business.